axoneme
Jump to navigation
Jump to search
Function
Structure
- axoneme contains many proteins & protein complexes necessary for function
- each axoneme consists of several microtubules aligned in parallel
- the microtubules are arranged in a characteristic pattern
- the microtubule or organized in pairs
- 9 sets of microtubule pairs form a ring around a central pair of microtubules (9 x 2 + 2 = 20 microtubles/axoneme)
- axonemes contain dynein dynein arms produce the force needed for bending. each dynein arm is anchored to a microtubule pair. dynein can cause microtubules to slide against each other in synchrony, with the mictrotubules on one side of the axonmene being pulled down & those on the other side pulled up, thus the axoneme as a whole can bend back & forth, resulting in ciliary/flagellar beating
- axonemes contain radial spokes radial spokes regulate motion of the axoneme 'T'-shaped complex thate projects from each set of outer microtubule pairs toward the central microtubule pair
More general terms
References
- ↑ Wikipedia http://en.wikipedia.org/wiki/Axoneme
- ↑ Porter ME, Sale WS. The 9 + 2 axoneme anchors multiple inner arm dyneins and a network of kinases and phosphatases that control motility. J Cell Biol. 2000 Nov 27;151(5):F37-42. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11086017
- ↑ Dillon RH, Fauci LJ. An integrative model of internal axoneme mechanics and external fluid dynamics in ciliary beating. J Theor Biol. 2000 Dec 7;207(3):415-30. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11082310
- ↑ Omoto CK, Gibbons IR, Kamiya R, Shingyoji C, Takahashi K, Witman GB. Rotation of the central pair microtubules in eukaryotic flagella. Mol Biol Cell. 1999 Jan;10(1):1-4. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9880321
- ↑ Rosenbaum JL, Cole DG, Diener DR. Intraflagellar transport: the eyes have it. J Cell Biol. 1999 Feb 8;144(3):385-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9971734
- ↑ Vogel G. News focus: Betting on cilia. Science. 2005 Oct 14;310(5746):216-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16223997