protein broad-minded; TBC1 domain family member 32 (TBC1D32, BROMI, C6orf170, C6orf171)

Function

• required for high-level Shh responses in the developing neural tube
• interacts with CDK20, which promotes CDK20 stability & function
• together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane & axoneme, allowing GLI2 to be properly activated in response to SHH signaling

Structure

• contains 1 Rab-GAP TBC domain
  • the Rab-GAP TBC domain appears to be inactive, probably due to a lack of the essential Arg & Gln in the catalytic finger motifs

Compartment

cytoplasm, cell projection, cilium (putative)

Alternative splicing

named isoforms=3

More general terms

• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=221322
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:221322
• UniProt: http://www.uniprot.org/uniprot/Q96NH3.html