ADP-ribosylation factor GTPase-activating protein 3; ARF GTPase activating protein 3; ARF GAP 3 (ARFGAP3)

Function

• GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1)
• hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes
• GAP activity stimulated by phosphatidylinositol-4,5-bisphosphate (PIP2)

Structure

contains 1 Arf-GAP domain

Compartment

• cytoplasm
• Golgi membrane
• peripheral membrane, cytoplasmic side. Note: also
• also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment

Expression

• widely expressed
• highest expression in endocrine glands (pancreas, pituitary, salivary gland, & prostate) & testis with a
• much higher expression in the testis than in the ovary
• expressed at higher level in adult thymus, brain & lung, than in corresponding fetal tissues
• expressed at lower level in spleen, heart, kidney & liver during development

Notes

• originally termed ARFGAP1

More general terms

• ADP-ribosylation factor GTPase activating protein (ARF-GAP)
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26286
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26286
• OMIM: https://mirror.omim.org/entry/612439
• UniProt: http://www.uniprot.org/uniprot/Q9NP61.html