Rho GTPase-activating protein 9; Rho-type GTPase-activating protein 9 (ARHGAP9)

Function

• GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. H
• has a substantial GAP activity toward CDC42 & RAC1 & less toward RHOA
• role in regulating adhesion of hematopoietic cells to the extracellular matrix
• interacts with FASLG

Structure

• contains 1 PH domain
• contains 1 Rho-GAP domain
• contains 1 SH3 domain
• contains 1 WW domain

Alternative splicing

named isoforms=4

Expression

• predominantly expressed in peripheral blood leukocytes, spleen, & thymus

More general terms

• rho GTPase-activating protein (rho-GAP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64333
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64333
• OMIM: https://mirror.omim.org/entry/610576
• UniProt: http://www.uniprot.org/uniprot/Q9BRR9.html