T-box transcription factor TBX21; T-box protein 21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM (TBX21, TBET, TBLYM)
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Function
- facilitates conversion of T helper-2 (Th2) cells into T helper-1 (Th1) cells
- controls expression of the TH1 cytokine, interferon-gamma
- initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs & by repressing the opposing TH2 programs
Structure
- contains 1 T-box DNA-binding domain
Compartment
Expression
T-cell specific
Pathology
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9UL17.html
- ↑ 2.0 2.1 Finotto S et al, Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295:336, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11786643
Szabo SJ et al, Distinct effects of T-bet in TH1 lineage commitment of IFN-gamma production in CD4 and CD8 T cells. Science 295:338, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11786644
Vogel G, Asthma research. Missing gene takes mice's breath away. Science 295:253, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11786617 - ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=30009