Delta & Notch-like epidermal growth factor-related receptor (DNER, BET, UNQ262/PRO299)

Function

• activator of the NOTCH1 pathway
• mediates neuron-glia interaction during astrocytogenesis (putative)
• interacts with AP1G1, NOTCH1

Structure

• contains 10 EGF-like domains contains 1 follistatin-like domain

Compartment

• cell membrane
• present on the membrane of dendrites & cell bodies
• excluded from axonal membrane
• found in early endosomes in the somatodendritic region

Expression

• expressed in brain, spinal cord, adrenal gland

More general terms

• cell surface receptor
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/607299
• UniProt: http://www.uniprot.org/uniprot/Q8NFT8.html