androstenedione in serum

Indications

• useful in conjunction with other tests in evaluation & management of androgen disorders
  • androgen excess
  • androgen deficiency
• monitoring of glucocorticoid treatment of congenital adrenal hyperplasia

Reference interval

• male (adult): 75-205 ng/dL (2.6-7.2 nmol/L)
• female (adult): 85-275 ng/dL (3.0-9.6 nmol/L)
• prepurtal: 8-50 ng/dL (0.3-1.7 nmol/L)

Increases

• clinical disorders
  • polycystic ovary disease (some)
  • hirsuitism (some)
  • congenital adrenal hyperplasia
  • Cushing's syndrome
  • ectopic ACTH-producing tumor
  • hyperplasia of ovarian stroma
  • ovarian tumor
  • osteoporosis in females
• pharmaceutical agents
  • in vivo effects
    • corticotropin, clomiphene, cyproterone acetate, levonorgestrel, metyrapone

Decreases

• clinical disorders
  • sickle cell anemia
  • adrenal failure
  • ovarian failure
• pharmaceutical agents
  • in vivo effects
    • dexamethasone

Specimen

• serum
• place on ice & process in 1 hour
• store frozen
• specimen should be collected at least 1 week before or after menstrual period

More general terms

• androstenedione in body fluid

Additional terms

• androstenedione