Krueppel-like factor 13; basic transcription element-binding protein 3; BTE-binding protein 3; Novel Sp1-like zinc finger transcription factor 1; RANTES factor of late activated T-lymphocytes 1; RFLAT-1; transcription factor BTEB3; transcription factor NSLP1 (KLF13, BTEB3, NSLP1)

Function

• represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1
• also represses transcription by interacting with the corepressor sin3A & HDAC1
• activates RANTES expression in T-cells
• phosphorylated

Structure

• the Ala/Pro-rich domain may contain discrete activation & repression subdomains & also can mediate protein-protein interactions
• belongs to the Sp1 C2H2-type Zn+2-finger protein family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus

Expression

ubiquitous

More general terms

• Krueppel-like factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51621
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51621
• OMIM: https://mirror.omim.org/entry/605328
• UniProt: http://www.uniprot.org/uniprot/Q9Y2Y9.html