proline-rich nuclear receptor coactivator 1; proline-rich protein 2; B4-2 protein (PNRC1, PROL2)

Function

• nuclear receptor coactivator
• signal transduction
• interacts with many nuclear receptors including: AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1/SF1, PGR, TR, RAR, RXR
• interacts with GRB2

Structure

• interaction between PNRC1 & nuclear receptors is dependent on the SH3 binding motif
• belongs to the PNRC family, PNRC1 subfamily

Compartment

nucleus

Expression

• expressed in liver, lung, fat, NK cell, T cells

More general terms

• transcriptional adaptor protein; transcriptional coactivator
• proline-rich protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10957
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10957
• OMIM: https://mirror.omim.org/entry/606714
• UniProt: http://www.uniprot.org/uniprot/Q12796.html