StAR-related lipid transfer protein 8; deleted in liver cancer 3 protein; DLC-3; START domain-containing protein 8; StARD8; START-GAP3 (STARD8, DLC3 ,KIAA0189)

Function

• accelerates GTPase activity of RHOA & CDC42
• does not accelerate GTPase activity of RAC1
• stimulates hydrolysis of phosphatidylinositol-4,5-bisphosphate by PLCD1
• binds both the SH2 & PTB domains of TNS1

Structure

• contains 1 Rho-GAP domain
• contains 1 START domain

Compartment

cell junction, focal adhesion

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest expression in kidney, lung & placenta

More general terms

• StAR-related lipid transfer protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9754
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9754
• OMIM: https://mirror.omim.org/entry/300689
• UniProt: http://www.uniprot.org/uniprot/Q92502.html