tensin-1 (TNS1 TNS)
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Function
- may be involved in cell migration, cartilage development & in linking signal transduction pathways to the cytoskeleton
- rapidly cleaved by calpain 2
- phosphorylated on Tyr
- binds to actin filaments
- binds vinculin[2]
- interacts with phospho-Tyr containing proteins
- interacts with STARD8
Structure
- contains 1 C2 tensin-type domain
- contains 1 phosphatase tensin-type domain
- contains 1 SH2 domain
Compartment
Expression
More general terms
References
- ↑ Davis S, Lu ML, Lo SH, Lin S, Butler JA, Druker BJ, Roberts TM, An Q, Chen LB. Presence of an SH2 domain in the actin-binding protein tensin. Science. 1991 May 3;252(5006):712-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1708917
- ↑ 2.0 2.1 Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514
- ↑ UniProt http://www.uniprot.org/uniprot/Q9HBL0.html