phospholipase C-delta 1 (PLCD1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1)

Function

• production of the second messenger molecules diacylglycerol & inositol 1,4,5-trisphosphate (IP3)
• essential for trophoblast & placental development

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
                    <-->
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol

Cofactor:

• binds 3 Ca+2 per subunit
• 2 of the Ca+2 are bound to the C2 domain (putative)

Structure

• contains 1 C2 domain
• contains 2 EF-hand domains
• contains 1 PH domain
• contains 1 PI-PLC X-box domain
• contains 1 PI-PLC Y-box domain

More general terms

• phospholipase C-delta

Database

• OMIM: https://mirror.omim.org/entry/602142
• UniProt: http://www.uniprot.org/uniprot/P51178.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5333