ubiquitin-conjugating enzyme E2 S; ubiquitin carrier protein S; ubiquitin-conjugating enzyme E2-24 kDa; ubiquitin-conjugating enzyme E2-EPF5; ubiquitin-protein ligase S (UBE2S, E2EPF, OK/SW-cl73)

Function

• accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins
• catalyzes Lys-11-linked polyubiquitination.
• essential factor of the anaphase promoting complex/cyclosome (APC/C)
• acts by specifically elongating Lys-11-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome & promoting mitotic exit
• also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro (unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo)
• also involved in ubiquitination & subsequent degradation of VHL, resulting in an accumulation of HIF1A.
• in vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except Lys-48-linked polyubiquitination
• protein modification; protein ubiquitination
• autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome
• component of the APC/C complex
• interacts with CDC20, FZR1/CDH1 & VHL

Structure

• belongs to the ubiquitin-conjugating enzyme family

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Component of

• anaphase promoting complex (APC, cyclosome)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27338
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27338
• OMIM: https://mirror.omim.org/entry/610309
• UniProt: http://www.uniprot.org/uniprot/Q16763.html