histone chaperone ASF1B (anti-silencing function protein 1 homolog B, hAsf1, hAsf1b, CCG1-interacting factor A-II, CIA-II, hCIA-II, ASF1B)

Function

• histone chaperone
• facilitates histone deposition & histone exchange & removal during nucleosome assembly & disassembly
• cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly
• does not participate in replication-independent nucleosome deposition mediated by ASF1A & HIRA
• required for spermatogenesis
• interacts with histone H3 (including both histone H3.1 & H3.3) & histone H4
• interacts with the CHAF1A, CHAF1B & RBBP4 subunits of the CAF-1 complex
• interacts with HAT1, NASP, TAF1, TLK1 & TLK2
• phosphorylated by TLK1 & TLK2

Structure

belongs to the ASF1 family

Compartment

nucleus

Expression

• highly expressed in testis
• lower levels in colon, small intestine & thymus

More general terms

• chaperonin; chaperone

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NVP2.html