histone acetyltransferase type B catalytic subunit (HAT1)

Function

• may play a role in telomeric silencing
• acetylates soluble but not nucleosomal H4 at Lys-5 & Lys-12
• acetylates histone H2A at Lys-5
• HAT1 has intrinsic substrate specificity that modifies Lys in recognition sequence GXGKXG
• heteromer of HAT1 & p46/HAT2 subunits

acetyl-CoA + histone <--> CoA + acetylhistone

Structure

belongs to the HAT1 family

Compartment

• nucleus; nuclear in S-phase
• cytoplasm

More general terms

• acyltransferase
• nuclear protein

Component of

• histone acetyltransferase complex type B

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8520
• OMIM: https://mirror.omim.org/entry/603053
• UniProt: http://www.uniprot.org/uniprot/O14929.html