DNA-directed RNA polymerase III subunit RPC6; RNA polymerase III subunit C6; DNA-directed RNA polymerase III subunit F; RNA polymerase III 39 kD subunit; RPC39 (POLR3F)

Function

• specific peripheral component of RNA polymerase 3
• role in sensing & limiting infection by intracellular bacteria & DNA viruses
• acts as nuclear & cytosolic DNA sensor involved in innate immune response
• can sense non-self dsDNA that serves as template for transcription into dsRNA
• the non-self RNA polymerase 3 transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type 1 interferon & NF- Kappa-B through the RIG-I pathway
• RPC3/POLR3C, RPC6/POLR3F & RPC7/POLR3G form an RNA polymerase 3 subcomplex (putative)
• interacts with TBP & TFIIIB90 & GTF3C4

Structure

• belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family

Compartment

nucleus (putative)

More general terms

• nuclear protein
• protein subunit

Component of

• RNA polymerase 3

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10621
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10621
• UniProt: http://www.uniprot.org/uniprot/Q9H1D9.html