transcription factor IIIB 90 kD subunit; TFIIIB90; hTFIIIB90; B-related factor 1; BRF-1; hBRF; TAF3B2; TATA box-binding protein-associated factor, RNA polymerase III, subunit 2 (BRF1, BRF, GTF3B, TAF3B2, TAF3C)

Function

• general activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters.
• isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA
• isoform 2 is required for transcription of the U6 promoter
• interacts with BDP1
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the TFIIB family
• contains 1 TFIIB-type zinc finger

More general terms

• transcription factor (TF)
• zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2972
• OMIM: https://mirror.omim.org/entry/604902
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2972
• UniProt: http://www.uniprot.org/uniprot/Q92994.html