general transcription factor 3C polypeptide 4; transcription factor IIIC-delta subunit; TF3C-delta; TFIIIC 90 kD subunit; TFIIIC90 (GTF3C4)

Function

• essential for RNA polymerase 3 to make a number of small nuclear RNAs & cytoplasmic RNAs, both cellular & viral origin including: 5S RNA, tRNA, & adenovirus-associated (VA) RNA
• has histone acetyltransferase activity (HAT) with unique specificity for free & nucleosomal H3
• may cooperate with GTF3C5 in facilitating the recruitment of TFIIIB & RNA polymerase through direct interactions with BRF1, POLR3C & POLR3F
• may be localized close to the A box
• part of the TFIIIC subcomplex TFIIIC2
• interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C & POLR3F

acetyl-CoA + histone  <--> CoA + acetylhistone

Structure

belongs to the TFIIIC subunit 4 family

Compartment

nucleus

More general terms

• protein subunit
• phosphoprotein
• acetyltransferase

Component of

• transcription factor IIIC (TFIIIC)

Database

• OMIM: https://mirror.omim.org/entry/604892
• UniProt: http://www.uniprot.org/uniprot/Q9UKN8.html