general transcription factor 3C polypeptide 1; TF3C-alpha; TFIIIC box B-binding subunit; transcription factor IIIC 220 kD subunit; TFIIIC 220 kD subunit; TFIIIC220; transcription factor IIIC subunit alpha (GTF3C1)

Function

• required for RNA polymerase 3-mediated transcription
• component of TFIIIC that initiates transcription complex assembly on tRNA & is required for transcription of 5S rRNA & other stable nuclear & cytoplasmic RNAs
• binds to the box B promoter element
• part of the TFIIIC subcomplex TFIIIC2
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the TFIIIC subunit 1 family

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• protein subunit
• nuclear protein
• phosphoprotein

Component of

• transcription factor IIIC (TFIIIC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2975
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2975
• OMIM: https://mirror.omim.org/entry/603246
• UniProt: http://www.uniprot.org/uniprot/Q12789.html