DNA-directed RNA polymerase III subunit RPC3; RNA polymerase III subunit C3; DNA-directed RNA polymerase III subunit C; RNA polymerase III 62 kD subunit; RPC62 (POLR3C)

Function

• specific core component of RNA polymerase 3
• may direct with other members of the subcomplex RNA polymerase 3 binding to the TFIIIB-DNA complex via interactions between TFIIIB & POLR3F
• may be involved either in the recruitment & stabilization of the subcomplex within RNA polymerase 3, or in stimulating catalytic functions of other subunits during initiation
• plays a key role in sensing & limiting infection by intracellular bacteria & DNA viruses
• acts as nuclear & cytosolic DNA sensor involved in innate immune response
• can sense non-self dsDNA that serves as template for transcription into dsRNA
• the non-self RNA polymerase 3 transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type 1 interferon & NF- Kappa-B through the RIG-I pathway
• interacts with GTF3C4 (putative)

Structure

• belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family

Compartment

nucleus (putative)

Pathology

• autoantibodies against POLR3C have been found in the sera of patients with systemic sclerosis (SSc)

More general terms

• nuclear protein
• protein subunit
• phosphoprotein

Component of

• RNA polymerase 3

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10623
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10623
• UniProt: http://www.uniprot.org/uniprot/Q9BUI4.html