general transcription factor 3C polypeptide 2; transcription factor IIIC-beta subunit; TF3C-beta; TFIIIC 110 kD subunit; TFIIIC110 (GTF3C2, KIAA0011)

Function

• required for RNA polymerase 3-mediated transcription
• component of TFIIIC that initiates transcription complex assembly on tRNA & is required for transcription of 5S rRNA & other stable nuclear & cytoplasmic RNAs
• may play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1
• part of the TFIIIC subcomplex TFIIIC2

Structure

contains 4 WD repeats

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• protein subunit
• phosphoprotein

Component of

• transcription factor IIIC (TFIIIC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2976
• OMIM: https://mirror.omim.org/entry/604883
• UniProt: http://www.uniprot.org/uniprot/Q8WUA4.html