immunoglobulin E [IgE] receptor or Fc epsilon [IgE] receptor-1

Function

• binds to the Fc region of immunoglobulins epsilon
• high affinity receptor
• responsible for initiating the allergic response
• binding of allergen to receptor-bound IgE leads to cell activation & the release of mediators (such as histamine)
• responsible for the manifestations of allergy
• the same receptor also induces the secretion of lymphokines
• associates with/activates lyn, src & yes

Structure

• tetramer of an alpha chain, a beta chain, & two disulfide linked gamma chains

More general terms

• Fc epsilon receptor
• oligomerizing protein

Additional terms

• immunoglobulin-E (IgE)