VEGF co-regulated chemokine 1 (C-X-C motif chemokine 17, Dendritic cell & monocyte chemokine-like protein, DMC, CXCL17, VCC1, UNQ473/PRO842)

Function

• role in angiogenesis & possibly in the development of tumors
• may be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes & immature dendritic cells into tissues
• may play a role in the innate defense against infections

Structure

• belongs to the intercrine alpha (chemokine CxC) family

Compartment

secreted

Expression

• detected in trachea, stomach, lung & skeletal muscle
• detected in intestine & in normal & asthmatic lung (at protein level)
• detected in fetal lung

Pathology

• breast cancer with 3-24 fold up-regulation
• up-regulated in duodenal mucosa during acute cholera

More general terms

• CXC chemokine; alpha chemokine

Component of

• carbinoxamine/dextromethorphan/pseudoephedrine/vegf co regulated chemokine 1

Database

• UniProt: http://www.uniprot.org/uniprot/Q6UXB2.html