protein diaphanous homolog 3; diaphanous-related formin-3; DRF3 (DIAPH3 DIAP3)

Function

• binds to GTP-bound form of Rho & to profilin
• recruits profilin to the membrane (Rho-dependent), where it promotes actin polymerization
• required for cytokinesis, stress fiber formation, & transcriptional activation of serum response factor
• DFR proteins couple Rho & Src tyrosine kinase during signaling & the regulation of actin dynamics
• DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction

Structure

• belongs to the formin homology family, diaphanous subfamily
• contains 1 DAD (diaphanous autoregulatory) domain
• contains 1 FH1 (formin homology 1) domain
• contains 1 FH2 (formin homology 2) domain
• contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain

Alternative splicing

named isoforms=7

More general terms

• formin homology family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81624
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81624
• UniProt: http://www.uniprot.org/uniprot/Q9NSV4.html