serine/threonine protein phosphatase 6 regulatory ankyrin repeat subunit A; PP6-ARS-A; serine/threonine protein phosphatase 6 regulatory subunit ARS-A; ankyrin repeat domain-containing protein 28; phosphatase interactor targeting protein hnRNP K; PITK (ANKRD28 KIAA0379)

Function

• putative regulatory subunit of protein phosphatase 6 (PP6)
• may be involved in the recognition of phosphoprotein substrates
• role in PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha
• selectively inhibits the phosphatase activity of PPP1C
• targets PPP1C to modulate HNRPK phosphorylation
• interacts with PPP1C & HNRPK
• interacts with PPP6C, PPP6R1 & PPP6R3

Structure

contains 27 ANK repeats

Compartment

• nucleus, nucleoplasm
• seems to be excluded from nucleoli

Alternative splicing

named isoforms=2

More general terms

• ankyrin repeat domain protein (ANKRD)
• nuclear protein
• phosphoprotein
• enzyme regulatory subunit

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23243
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23243
• OMIM: https://mirror.omim.org/entry/611122
• UniProt: http://www.uniprot.org/uniprot/O15084.html