serine/threonine protein phosphatase 6 catalytic subunit; PP6C (PPP6C, PPP6)

Function

• catalytic subunit of protein phosphatase 6 (PP6)
• N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1
• downregulates MAP3K7 kinase activation of IL1 signaling by dephosphorylation of MAP3K7
• interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1, PPP6R2 & PPP6R3

Cofactor:

• binds 1 iron ion per subunit (putative)
• binds 1 Mn+2 per subunit (putative)

Structure

• belongs to the PPP phosphatase family, PP-6 (PP-V) subfamily

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed in all tissues tested
• highest expression levels in testis, heart, kidney, brain, stomach, liver & skeletal muscle
• lowest expression in placenta, lung colon & spleen
• regulated by IL2/interleukin-2 in peripheral blood T cells

More general terms

• serine/threonine phosphatase
• enzyme catalytic subunit

Component of

• serine/threonine protein phosphatase 6

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5537
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5537
• OMIM: https://mirror.omim.org/entry/612725
• UniProt: http://www.uniprot.org/uniprot/O00743.html