immunoglobulin-binding protein 1; CD79a-binding protein 1; B-cell signal transduction molecule alpha 4; protein alpha-4; renal carcinoma antigen NY-REN-16 (IGBP1, IBP1)

Function

• associated with surface IgM-receptor
• may be involved in signal transduction
• may be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases
• phosphorylated (putative)
• associates with PP2A-alpha & PP2A-beta catalytic subunits, & with PP4 & PP6. interacts with MID1 & MID2

Structure

belongs to the IGBP1/TAP42 family

Compartment

cytoplasm (putative)

Expression

• ubiquitously expressed with highest levels in heart, skeletal muscle & pancreas

Pathology

• defects in IGBP1 are the cause of agenesis of the corpus callosum with mental retardation, ocular coloboma & micrognathia

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3476
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3476
• OMIM: https://mirror.omim.org/entry/300139
• OMIM: https://mirror.omim.org/entry/300472
• UniProt: http://www.uniprot.org/uniprot/P78318.html