carbohydrate sulfotransferase 3; chondroitin 6-O-sulfotransferase 1; C6ST-1; chondroitin 6-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0; GST-0 (CHST3)

Function

• catalyzes transfer of sulfate to position 6 of the N-acetylgalactosamine (galNAc) residue of chondroitin
• chondroitin sulfate constitutes the predominant proteoglycan present in cartilage & is distributed on the surfaces of many cells & extracellular matrix
• can also sulfate galactose residues of keratan sulfate & the galactose residues in sialyl N-acetyllactosamine (sialyl lacNAc) oligosaccharides
• may play a role in the maintenance of naive T-lymphocytes in the spleen

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate

Structure

• belongs to the sulfotransferase 1 family gal/GlcNAc/galNAc subfamily

Compartment

• Golgi membrane
• single-pass type 2 membrane protein (putative)

Expression

• widely expressed in adult tissues
• expressed in heart, placenta, skeletal muscle & pancreas
• also expressed in various immune tissues such as spleen, lymph node, thymus & appendix

Pathology

• defects in CHST3 are a cause of spondyloepiphyseal dysplasia with congenital joint dislocations

More general terms

• carbohydrate sulfotransferase (CHST)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9469
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9469
• OMIM: https://mirror.omim.org/entry/143095
• OMIM: https://mirror.omim.org/entry/603799
• UniProt: http://www.uniprot.org/uniprot/Q7LGC8.html