disks large homolog 2; postsynaptic density protein PSD-93; channel-associated protein of synapse-110; chapsyn-110 (DLG2)

Function

• required for perception of chronic pain through NMDA receptor signaling
• regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord
• interacts with
  • cytoplasmic tail of NMDA receptor subunits
  • inward rectifying K+ channels
• role in synaptic stability at cholinergic synapses
• component of postsynaptic protein scaffold of excitatory synapses (putative)
• palmitoylation of isoform 1 is not required for targeting to postsynaptic density (putative)
• interacts through its PDZ domains with NETO1
• interacts with NOS1/nNOS through second PDZ domain (putative)
• interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains
• interacts with FRMPD4 (via C-terminus)

Structure

• isoform 2 has an L27 domain close to N-terminus
• belongs to the MAGUK family
• contains 1 guanylate kinase-like domain
• contains 3 PDZ domain (DHR domain)s
• contains 1 SH3 domain

Compartment

• membrane, lipid-anchor (putative)
• cell junction
• synapse, postsynaptic cell membrane, postsynaptic density (putative)
• concentrated in soma & postsynaptic density of a subset of neurons (putative)

Alternative splicing

named isoforms=4

More general terms

• scaffold protein
• phosphoprotein

Additional terms

• discs large homolog
• disks large-associated protein 1; DAP-1; guanylate kinase-associated protein; hGKAP; SAP90/PSD-95-associated protein 1; SAPAP1; PSD-95/SAP90-binding protein 1 (DLGAP1 DAP1 GKAP)
• drosophila discs large [dlg] protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1740
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1740
• OMIM: https://mirror.omim.org/entry/603583
• UniProt: http://www.uniprot.org/uniprot/Q15700.html