neuropilin & tolloid-like protein 1; brain-specific transmembrane protein containing 2 CUB & 1 LDL-receptor class A domains protein 1 (NETO1 BTCL1)

Function

• development &/or maintenance of neuronal circuitry
• accessory subunit of NMDA receptor
• regulates long-term potentiation & cognition, at least in the context of spatial learning & memory
• interacts with PLZ domains of DLG2, DLG3 & DLG4 via its C-terminal TRV domain
• interacts with GRIN2A & GRIN2B via its CUB domains (putative)

Structure

• contains 2 CUB domains
• contains 1 LDL-receptor class A domain

Compartment

• isoform 2:
  • cell membrane
  • cell junction, synapse
  • postsynaptic cell membrane, postsynaptic density; component of the postsynaptic density (PSD) of excitatory synapses (putative)
  • single-pass type 1 membrane protein (putative)
• isoform 3:
  • cell membrane; single-pass type 1 membrane protein
• isoform 1: secreted (putative)

Alternative splicing

named isoforms=3

Expression

• isoform 1 & isoform 2 are retina-specific
• isoform 3 is found in retina as well as at lower levels in adult & fetal brain

More general terms

• membrane protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81832
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81832
• OMIM: https://mirror.omim.org/entry/607973
• UniProt: http://www.uniprot.org/uniprot/Q8TDF5.html