GRB2-associated-binding protein 1; GRB2-associated binder 1; growth factor receptor bound protein 2-associated protein 1 (GAB1)

Function

• adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-tyrosine kinases
• plays a role in FGFR1 signaling
• probably involved in signaling by EGF receptor (EGFR) & insulin receptor (INSR)
• phosphorylated in response to FGFR1 activation
• phosphorylated on Tyr by EGFR & INSR
• Tyr phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains
• phosphorylated on Tyr by HCK upon IL6 signaling
• interacts with GRB2 & with other SH2-containing proteins
• interacts with phosphorylated LAT2
• interacts with PTPRJ
• identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 & SOS1
• interacts (phosphorylated) with PTPN11
• interacts with HCK

Structure

• belongs to the GAB family
• contains 1 PH domain

Alternative splicing

named isoforms=2

More general terms

• GRB2-associated binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2549
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2549
• OMIM: https://mirror.omim.org/entry/604439
• UniProt: http://www.uniprot.org/uniprot/Q13480.html