zinc finger protein 384; CAG repeat protein 1; CAS-interacting zinc finger protein; nuclear matrix transcription factor 4; nuclear matrix protein 4; trinucleotide repeat-containing gene 1 protein (ZNF384, CAGH1, CIZ, NMP4, TNRC1)

Function

• transcription factor
• binds the consensus DNA sequence [GC]AAAAA
• seems to bind & regulate the promoters of MMP1, MMP3, MMP7 & COL1A1 (putative)
• interacts with BCAR1 (putative)

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 8 C2H2-type Zn+2 fingers

Compartment

nucleus (putative)

Alternative splicing

• named isoforms=3
• additional isoforms seem to exist

Pharmacology

• ZNF384 is a potential therapeutic target for psoriasis* & Alzheimer's disease* by regulating PPARG, ZNF415, HLX,& ANHX

* see disease interactions of psoriasis with Alzheimer's disease

More general terms

• nuclear protein
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=171017
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:171017
• OMIM: https://mirror.omim.org/entry/609951
• UniProt: http://www.uniprot.org/uniprot/Q8TF68.html