H2.0 (Drosophila)-like homeobox protein; homeobox protein HLX1; homeobox protein HB24, (HLX, HLX1)

Function

• transcription factor required for
  • TBX21/T-bet-dependent maturation of Th1 cells
  • maintenance of Th1-specific gene expression
• involved in embryogenesis & hematopoiesis

Structure

• belongs to the H2.0 homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (putative)

Expression

• low level in normal B & T-cells
• high level in activated lymphocytes & monocytes
• also found in thymus, tonsil, bone marrow, developing vessels, & fetal brain

More general terms

• homeobox protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3142
• OMIM: https://mirror.omim.org/entry/142995
• UniProt: http://www.uniprot.org/uniprot/Q14774.html