zinc finger protein 415 (ZNF415)

Function

• role in transcriptional regulation
• transcriptional activity differs among the various isoforms
• all isoforms except isoform 3 seem to suppresst transcriptional activities of AP-1 & p53

Structure

contains 12 C2H2-type zinc fingers

Compartment

• nucleus, cytoplasm
• isoforms 1, 2, 4 & 5 show both nuclear & cytoplasmic localization
• isoform 3 localizes only to nucleus

Alternative splicing

named isoforms=5

Expression

• expressed in all tissues examined
• isoforms are differentially expressed
• isoform 3 & 5 > isoform 4 > isoform 2 >isoform 1

More general terms

• C2H2 type zinc finger protein
• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/Q09FC8.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55786