zinc finger protein 306; zinc finger protein with KRAB & SCAN domains 3; zinc finger & SCAN domain-containing protein 13; zinc finger protein 309; zinc finger protein 47 homolog; Zf47; Zfp-47 (ZKSCAN3, ZFP47, ZNF306, ZNF309, ZSCAN13)

Function

• acts as a transcriptional regulator
• binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3'
• associates with chromatin at the ITGB4 & VEGF promoters

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 7 C2H2-type Zn+2 fingers
• contains 1 KRAB domain
• contains 1 SCAN box domain

Compartment

nucleus

Expression

• expressed in colorectal cancers (at protein level)

Pathology

• activates transcription of genes associated with colon cancer progression

More general terms

• C2H2 type zinc finger protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80317
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80317
• OMIM: https://mirror.omim.org/entry/612791
• UniProt: http://www.uniprot.org/uniprot/Q9BRR0.html