zinc finger protein 291; S phase cyclin A-associated protein in the endoplasmic reticulum; S phase cyclin A-associated protein in the ER (SCAPER, KIAA1454, ZNF291, MSTP063)

Function

• CCNA2/CDK2 regulatory protein
  • transiently maintains CCNA2 in the cytoplasm
  • phosphorylated in vitro by the CCNA2/CDK2 complex
  • interacts with CCNA2/CDK2 complex at multiple phases of the cell cycle, including S & G2/M
• does not interact with CCNA2/CDC2, CCNB1/CDC2 or CCNE1/CDK2 complexes

Structure

contains 1 C2H2-type Zn+2 finger

Compartment

• endoplasmic reticulum, nucleus
• predominantly located in the endoplasmic reticulum
• only a small portion is detected in the nucleus

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest expression in testis
• expressed at each stage of the cell cycle, including G0
  • expression is somewhat higher in late G1 & S phases than in G0

More general terms

• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=49855
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:49855
• OMIM: https://mirror.omim.org/entry/611611
• UniProt: http://www.uniprot.org/uniprot/Q9BY12.html