cyclin A2 (CCNA2)
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Function
- essential for the control of the cell cycle at the G1/S (start) & the G2/M (mitosis) transitions
- interacts with the CDK2 & CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex
- the cyclin subunit imparts substrate specificity to the complex
- when associated with CDK2 (but not with CDC2), interacts with SCAPER
Structure
belongs to the cyclin family, cyclin AB subfamily
Compartment
- nucleus, cytoplasm
- cytoplasmic when associated with SCAPER
Expression
- cyclin A is an S-phase specific cyclin with maximum concentrations expressed in mid S-phase[3]
- expression under transcriptional control[2]
- accumulates steadily during G2 & is abruptly destroyed at mitosis
More general terms
Component of
References
- ↑ Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147
- ↑ 2.0 2.1 Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9;374(6518):131-4. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7877684
- ↑ 3.0 3.1 Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7677168
- ↑ UniProt http://www.uniprot.org/uniprot/P20248.html