zinc finger protein 265; zinc finger Ran-binding domain-containing protein 2; zinc finger, splicing (ZRANB2, ZIS, ZNF265)

Function

• splice factor required for alternative splicing of TRA2B/SFRS10 transcripts
• may interfere with constitutive 5'-splice site selection
• isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR
• interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 & CLK1

Structure

• the RanBP2-type Zn+2 fingers mediate binding to RNA
• belongs to the ZRANB2 family
• contains 2 RanBP2-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• zinc finger protein
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9406
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9406
• OMIM: https://mirror.omim.org/entry/604347
• UniProt: http://www.uniprot.org/uniprot/O95218.html