splicing factor, arginine/serine-rich 17A; protein XE7; B-lymphocyte antigen; 721P (SFRS17A, CXYorf3, DXYS155E, XE7, AKAP17A)

Function

• splice factor regulating alternative splice site selection for certain mRNA precursors
• component of the spliceosome
• interacts with ZRANB2 & SFRS1/ASF through its Arg/Ser-rich domain

Structure

• monmer
• contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus speckle

Alternative splicing

• named isoforms=3
• one of more may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• widely expressed
• found in heart, brain, lung, liver, skeletal muscle, kidney & pancreas
• expressed in activated B-cells & placenta

Genetics

• the gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X & Y chromosomes

Notes

• was originally thought to be a cell surface protein involved in B-cell activation

More general terms

• splicing factor; snRNP-associated protein
• RNA-binding protein
• phosphoprotein

Component of

• spliceosome

Database

• UniProt: http://www.uniprot.org/uniprot/Q02040.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8227
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8227
• OMIM: https://mirror.omim.org/entry/312095
• OMIM: https://mirror.omim.org/entry/465000