polycomb group RING finger protein 2; DNA-binding protein mel-18; RING finger protein 110; zinc finger protein 144 (PCGF2, MEL18, RNF110, ZNF144)

Function

• transcriptional repressor
• binds specifically to the DNA sequence 5'-GACTNGACT-3'
• has tumor suppressor activity
• may play a role in control of cell proliferation &/or neural cell development
• regulates proliferation of early T progenitor cells by maintaining expression of HES1
• role in antero-posterior specification of the axial skeleton
• negative regulation of the self-renewal activity of hematopoietic stem cells
• component of the polycomb group (PcG) multiprotein PRC1 complex
• phosphorylated
• unphosphorylated protein forms homodimers (putative)

Structure

contains 1 RING-type Zn+2 finger

Compartment

nucleus

Expression

• detected in all tissues examined
• high expression in placenta lung & kidney
• low expression in liver, pancreas & skeletal muscle

More general terms

• DNA-binding protein
• transcriptional silencer (transcriptional repressor)
• ring finger protein

Component of

• Polycomb group multiprotein PRC1 complex (PcG PRC1 complex, hPRC-H, PcG repressive complex 1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7703
• OMIM: https://mirror.omim.org/entry/600346
• UniProt: http://www.uniprot.org/uniprot/P35227.html