twist-related protein 2 (dermis expressed protein 1, dermo-1, DERMO1)

Function

• binds to the E-box consensus sequence 5'-CANNTG-3' as heterodimer
• inhibits transcriptional activation by MYOD1, MYOG, MEF2A & MEF2C
• represses expression of proinflammatory cytokines such as TNFA & IL1B
• involved in postnatal glycogen storage and energy metabolism
• inhibits premature or ectopic differentiation of preosteoblast cells during osteogenesis
• efficient DNA binding requires dimerization with another bHLH protein
• forms a heterodimer with TCF3/E12
• interacts with MEF2C

Compartment

• nucleus, mainly nuclear during embryonic development
• cytoplasmic in adult tissues.

Expression

• in the embryo, highly expressed in chondrogenic cells
• in embryonic skin, expressed in undifferentiated mesenchymal layer beneath epidermis which later develops into dermis
• expressed in early myeloid cells but not in lymphoid cells in the liver
• expression also detected in secretory ependymal epithelium of choroid plexus primordium
• in adults, expressed in secreting glandular tissues & tubules

More general terms

• DNA-binding protein

Additional terms

• twist-related protein

Database

• OMIM: https://mirror.omim.org/entry/607556
• UniProt: http://www.uniprot.org/uniprot/Q8WVJ9.html