homeobox protein cut-like 1; CCAAT displacement protein; CDP; homeobox protein cux-1 (CUX1, CUTL1)

Function

• probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression
• may act by preventing binding of positively-activing CCAAT factors to promoters
• component of nf-munr repressor
• binds to the matrix attachment regions (MARs) (5' & 3') of the immunoglobulin heavy chain enhancer
• represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer (putative)
• interacts with BANP (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the CUT homeobox family
• contains 3 CUT DNA-binding domains
• contains 1 homeobox DNA-binding domain
• Asn-1290 may participate in regulating DNA-binding activity by promoting homo- & heterodimerization

Compartment

nucleus

Alternative splicing

• named isoforms=7
• additional isoforms seem to exist

Notes

• both the CASP protein & the CCAAT displacement protein appear to have the gene symbol CUX1 with synonym CUTL1

More general terms

• DNA-binding protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1523
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1523
• OMIM: https://mirror.omim.org/entry/116896
• UniProt: http://www.uniprot.org/uniprot/P39880.html