Bcl-2-like protein 10; Bcl2-L-10; apoptosis regulator Bcl-B; anti-apoptotic protein NrH (BCL2L10, BCLB)

Function

• promotes cell survival
• associates with bcl-2, bcl-xL, bax
• inhibits apoptosis induced by bax but not by bak
• has weak interactions with Apaf-1 but may not play significant role in suppressing Apaf-1

Structure

belongs to the Bcl-2 family

Compartment

mitochondria, nuclear membrane

Expression

-widely expressed in human adult tissues

• preferentially expressed in lungs, liver & kidneys

More general terms

• bcl-2 subfamily protein
• anti apoptotic protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10017
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10017
• OMIM: https://mirror.omim.org/entry/606910
• UniProt: http://www.uniprot.org/uniprot/Q9HD36.html