collagen 16 alpha-1 (COL16A1)

Function

• role in mediating cell attachment & inducing integrin-mediated cellular reactions, such as cell spreading & alterations in cell morphology
• Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains
• interacts with FBN1, fibronectin & integrins ITGA1/ITGB1 & ITGA2/ITGB1
• integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3

Structure

• glycosylated
• homotrimer
• 18 different domains
  • 9 triple-helical domains (COL9 to COL1)
  • 10 non-triple-helical domains (NC10 to NC1)
• numerous interruptions in the triple helix may make COL15A1 either elastic or flexible
• belongs to the fibril-associated collagens with interrupted helices (FACIT) family
• contains 1 TSP N-terminal (TSPN) domain

Compartment

• secreted, extracellular space, extracellular matrix

Alternative splicing

named isoforms=2

Expression

• in papillary dermis, component of specialized fibrillin-1- containing microfibrils
• in cartilage matrix, localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens
• in the placenta, found in the amnion
  • within the amnion, it is found in an acellular, relatively dense layer of a complex network of reticular fibers
  • also located in a fibroblast layer beneath this dense layer
• present in tissues in association with other types of collagen
• transiently elevated expression during gestation, & decrease at term

More general terms

• collagen subunit
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1307
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1307
• OMIM: https://mirror.omim.org/entry/120326
• UniProt: http://www.uniprot.org/uniprot/Q07092.html