collagen 15 alpha-1; contains: endostatin; restin (COL15A1)

Function

• structural protein
  • stabilizes microvessels & muscle cells, both in heart & in skeletal muscle
• cleaved to form endostatin, a peptied that potently inhibits angiogenesis
• Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains

Structure

• O-glycosylated; with core 1 or possibly core 8 glycans
• an N-terminal peptide contains chondroitin sulfate
• trimer; disulfide-linked
• belongs to the multiplexin collagen family
• contains 1 TSP N-terminal (TSPN) domain

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

• expressed predominantly in internal organs such as adrenal gland, pancreas & kidney

More general terms

• collagen subunit
• glycoprotein

Additional terms

• endostatin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1306
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1306
• OMIM: https://mirror.omim.org/entry/120325
• UniProt: http://www.uniprot.org/uniprot/P39059.html