endostatin
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Function
- inhibits angiogenesis, endothelial proliferation & tumor growth
- may inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling
Expression
- seems to be derived from either
- collagen 15 alpha-1
- C-terminal fragment of collagen 18 alpha-1
More general terms
Additional terms
- collagen 15 alpha-1; contains: endostatin; restin (COL15A1)
- collagen 18 alpha-1; contains: endostatin (COL18A1)
References
- ↑ UniProt http://www.uniprot.org/uniprot/P39059.html
- ↑ UniProt http://www.uniprot.org/uniprot/P39060.html
- ↑ O'Reilly MS et al Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997 Jan 24;88(2):277-85. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9008168