MAGUK p55 subfamily member 7 (MPP7)

Function

• acts as an important adapter that promotes epithelial cell polarity & tight junction formation via its interaction with DLG1
• involved in the assembly of protein complexes at sites of cell-cell contact
• heterodimer; able to heterodimerize via its C-terminal L27 domain with LIN7A, LIN7B & LIN7C
• forms a tripartite complex composed of DLG1, MPP7 & LIN7 (LIN7A or LIN7C)
• interacts with DLG1 via its N-terminal L27 domain
• interacts with MPP5 & INADL/PATJ

Structure

• belongs to the MAGUK family
• contains 1 guanylate kinase-like domain
• contains 2 L27 domains
• contains 1 PDZ (DHR) domain
• contains 1 SH3 domain

Compartment

membrane; peripheral membrane protein. cell junction, tight junction. cell junction, adherens junction

Expression

down-regulated in patients suffering of passive heymann nephritis (at protein level)

More general terms

• MAGUK p55 subfamily

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1430
• UniProt: http://www.uniprot.org/uniprot/Q5T2T1.html