alpha-taxilin (TXLNA, TXLN, HMW BCGF)

Function

• intracellular vesicle traffic (putative)
• Ca+2-dependent exocytosis in neuroendocrine cells
• interacts with syntaxins that do not form the SNARE complex
• binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A, STX4A, but NOT when these proteins are complexed with SNAP25, VAMP2 or STXBP1

Structure

belongs to the taxilin family

Expression

• ubiquitous
• expressed in highest amounts in heart, kidney, liver, pancreas

Notes

originally identified as IL14

More general terms

• taxilin (TXLN)
• phosphoprotein

Additional terms

• beta-taxilin (muscle-derived protein 77, hMDP77, TXLNB, C6orf198, MDP77)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=200081
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:200081
• OMIM: https://mirror.omim.org/entry/608676
• UniProt: http://www.uniprot.org/uniprot/P40222.html