tumor necrosis factor receptor superfamily member 12A; fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD266 (TNFRSF12A, FN14)

Function

• receptor for TNFSF12/TWEAK
• weak inducer of apoptosis in some cell types
• promotes angiogenesis & proliferation of endothelial cells
• may modulate cellular adhesion to matrix proteins
• associates with TRAF1 & TRAF2, & probably also with TRAF3

Structure

contains 1 TNFR-Cys repeat

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• highly expressed in heart, placenta & kidney
• intermediate expression in lung, skeletal muscle & pancreas
• induced by FGF-1 & phorbol ester

More general terms

• tumor necrosis factor [TNF] receptor family
• immediate early response protein
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5133
• OMIM: https://mirror.omim.org/entry/605914
• UniProt: http://www.uniprot.org/uniprot/Q9NP84.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51330