UBX domain-containing protein 4; UBX domain-containing protein 2; Erasin (UBXN4, KIAA0242, UBXD2, UBXDC1)

Function

• role in endoplasmic reticulum-associated protein degradation (ERAD)
• phosphorylated upon DNA damage, probably by ATM or ATR
• directly interacts with VCP

Structure

• the UBX domain is required for interaction with VCP
• the transmembrane domain also contains the signal for ER targeting

contains 1 UBX domain

Compartment

• endoplasmic reticulum membrane
• peripheral membrane protein
• nuclear envelope
• Both the N-terminus & the C-terminus face the cytosol
• also found in the nucleus envelope contiguous to the ER

Expression

• expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas
• induced by ER stress-inducing reagents, such as tunicamycin, thapsigargin, DTT & the Ca+2ophore A23187 (at protein level)

Pathology

• UBXN4 accumulates in Alzheimer disease-afflicted brains (at protein level)

More general terms

• UBX domain-containing protein (UBXD)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23190
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23190
• OMIM: https://mirror.omim.org/entry/611216
• UniProt: http://www.uniprot.org/uniprot/Q92575.html